H. pylori - Ace Therapeutics
The Bacterial Balancing Act: H. pylori and Probiotics
Online Inquiry

The Bacterial Balancing Act: H. pylori and Probiotics


In the intricate world of human health, the balance of bacteria within our bodies plays a crucial role. Among the many microorganisms that reside in our digestive system, Helicobacter pylori (H. pylori) and probiotics have gained attention for their unique impact on our well-being. In this article, we will delve into the fascinating interplay between H. pylori and probiotics, shedding light on their roles and how they influence our overall health.

H. pylori: The Stealthy Stomach Inhabitant

H. pylori is a type of bacterium that has been coexisting with humans for thousands of years, primarily taking up residence in the stomach lining. Although it has earned a notorious reputation for causing stomach ulcers and gastritis, not all strains of H. pylori are harmful. In fact, some strains may even be beneficial.

The good and the bad of Helicobacter pylori

There's a delicate balance to the presence of H. pylori in our stomachs. On one hand, this bacterium can lead to digestive issues and increase the risk of peptic ulcers and gastric cancer if it becomes too abundant or aggressive. On the other hand, some studies suggest that H. pylori might offer protection against esophageal reflux disease (GERD) and other digestive disorders.

The Immune System's Diplomat

H. pylori has also been called the "immune system's diplomat" because it can influence our immune response. By interacting with the immune system in the stomach lining, H. pylori may play a role in regulating our body's immune balance, potentially preventing excessive immune reactions.

Probiotics: The Friendly Microbes

Antagonistic mechanism of probiotic against H. pylori.Figure 1. Antagonistic mechanism of probiotic against H. pylori. (Jianfu Ji, et al.; 2020)

Probiotics, in contrast, are the friendly microbes that support various aspects of our health, primarily by maintaining a balanced gut microbiome. They can be found in various fermented foods like yogurt, kefir, and sauerkraut or in supplement form.

Gut Guardians

Probiotics primarily reside in our intestines, and they have a significant impact on our digestive health. These beneficial bacteria help break down food, absorb nutrients, and maintain a healthy gut environment.

A Shield for the Immune System

Probiotics also interact with our immune system. They help stimulate the production of antibodies and other immune cells, bolstering our defenses against harmful pathogens and infections.

The Relation of H. pylori and Probiotics

Now that we've introduced both H. pylori and probiotics, let's explore how these two players interact within our bodies.


Studies suggest that a balanced gut microbiome, with the presence of beneficial probiotics, can help keep H. pylori in check. Probiotics may create an environment less conducive to H. pylori's aggressive growth, potentially reducing the risk of ulcers and gastritis.

Immune Regulation

Probiotics, by supporting a healthy immune system, can indirectly influence H. pylori's impact. A well-balanced immune system may be better equipped to manage H. pylori infections without causing excessive inflammation or harm to the stomach lining.

The Anti-Inflammatory Effect

Some probiotic strains have demonstrated anti-inflammatory properties. This is particularly important in the context of H. pylori infections, as inflammation in the stomach lining is a key factor in the development of ulcers and gastritis.

The Probiotic Shield

Probiotics may also serve as a protective shield against the side effects of antibiotic treatments commonly used to eradicate H. pylori infections. Antibiotics can disrupt the balance of the gut microbiome, leading to digestive disturbances. Probiotic supplementation during and after antibiotic treatment can help restore this balance.


In the intricate relation of human health, the roles of H. pylori and probiotics are complex and multifaceted. H. pylori, often seen as a bad, may not be entirely devoid of virtue, as some strains may offer benefits to our digestive and immune systems. Probiotics, the friendly microbes, act as essential partners in maintaining a balanced gut microbiome and supporting our immune defenses. The key takeaway is that balance is crucial. Neither the complete eradication of H. pylori nor the excessive proliferation of this bacterium is ideal. Instead, fostering a harmonious relationship between H. pylori and probiotics is a promising avenue for promoting overall health. As research in this field continues to unfold, a deeper understanding of this intricate bacterial balancing act may hold the key to optimizing our well-being.


  1. Jianfu Ji, et al.; Using Probiotics as Supplementation for Helicobacter pylori Antibiotic Therapy. Int. J. Mol. Sci. 2020, 21(3), 1136.

※ All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.